In SharePoint 2010 you can change your default search center for My Sites (mysites). In my case, I needed to setup a new Search Center on the My Site host.

The address is:
http://mysite.sharepointed.com/search/

To update your My Site search destination goto:
Central Administration –> Application Management –> Service Applications – Manage service application –> User Profile Service.

Under the My Site Settings, click on Setup My Sites.
Preferred Search Center

My URL looks like this:
http://mysite.sharepointed.com/search/pages/

I had to add to pages/ path to satisify the value being sent from the My Site people search box.